Tryptase
Ordering Recommendation
Measure total tryptase to confirm mast cell activation in diseases such as mastocytosis, anaphylaxis, urticaria, and asthma. Not generally used acutely except where diagnosis is unclear. Useful in prognosis of systemic mastocytosis.
New York DOH Approval Status
Specimen Required
Serum separator tube.
Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Frozen.
After separation from cells: Ambient: 48 hours; Refrigerated: 72 hours; Frozen: 1 month
Methodology
Quantitative Fluorescent Enzyme Immunoassay
Performed
Sun-Sat
Reported
1-2 days
Reference Interval
Less than 11.0 µg/L
Interpretive Data
FDA
Note
This test measures total tryptase and does not distinguish between the alpha and beta protein types. Samples should preferably be collected between 15 minutes and three hours after the event suspected to have caused mast cell activation.
Hotline History
CPT Codes
83520
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0099173 | Tryptase | 21582-2 |
Aliases
- Total Tryptase
- Tryptase, Autopsy (Tryptase)